On December 1st, 2019, the USEF ban on the use of Medroxyprogesterone Acetate (MPA) took effect. For horses competing at USEF-licensed competitions that have been relying on MPA, it’s time to find another option. With WEF just around the corner, we’ve gathered some show-safe solutions to help you and your horse have a successful winter show season!


Venus by Cavalor is a liquid product formulated to help manage hormonal fluctuations and mood swings in mares. A unique formula of natural ingredients and herbal extracts regulate the mare’s estrus cycle, helping reduce irregularities without blocking normal bodily processes. Venus has a relaxation effect on the horse, preventing mood-related behavior, and making the mare you love easier to manage.

Venus is FEI-safe and available in a 500mL or 2L bottle.

Perfect Harmony

Perfect Harmony EQ from Perfect Products uses nutraceutical ingredients to naturally mimic the relaxing and behavior-related effects of Progesterone therapy. Hormonal imbalance can negatively affect a horse’s behavior and performance. Perfect Harmony EQ supports balanced hormonal functions to help curtail hormone-related aggression, agitation, or sullenness. This quick-acting supplement may lead to improved behavior in as little as 2 days after the first dose and continues to strengthen with daily use. 

Perfect Harmony EQ does not contain prohibited ingredients or require drug reports for use at competitions. This supplement can also safely be combined with other Perfect Products calming products such as Perfect Prep EQ. Available in 16oz, 32oz, and 64oz.


Regu-Mate from Merck works to suppress estrus in mares and allows for the predictable occurrence of estrus once the drug has been withdrawn. The Regu-Mate solution contains 2.2mg of altrenogest per 1 ml of solution. Altrenogest is a potent synthetic hormone and is used to control estrus cycles in mares, attain regular breeding cycles in mares, and suppress prolong estrus conditions.

Regu-Mate is available in a 1,000mL bottle and requires a prescription from your veterinarian before purchase. Don’t forget the Regu-Mate Dosing Gun!


FDA-approved Altren (altrenogest) provides safe, effective suppression of estrus in mares. This product is 95% effective after 3 days of treatment. The only FDA-approved generic alternative to Regu-Mate made in the USA. This cost-effective alternative to Regu-Mate is comprised of the same formulation and active ingredients. 

Altren is available in a 1,000mL bottle and requires a prescription from your veterinarian before purchase.

Learn More

To understand more about the USEF’s decision to ban MPA, read their article here. You can shop our show-safe replacements for MPA online at FarmVet.com 24/7 or call one of our friendly Sales Associates at 1-888-837-3626 from Monday-Friday 8am-5pm CST. You can also email your order to info@farmvet.com.